Haishi Cao, Ph.D.

Professor, Organic Chemistry

Office: BHS 411D   |    Phone: (308) 865-8105   |    Email: caoh1@usa-kj.com

Haishi Cao

Biography

Education

Ph.D., Organic Chemistry, New Mexico Institute of Mining & Technology, 2004
M.Sc., Biochemistry, Jilin University (China), 1999
B.Sc., Biochemistry, Jilin University (China), 1995

Research Interest

Fluorescence sensing, Chemosensor, 分子识别和检测有毒离子和生物分子.

Faculty Appointments

2017-至今，南京大学化学系教授
2012-2017，副教授，化学系，bet36365体育
2007-2012，化学系助理教授

Research Area

我的研究方向是在光谱信息的基础上，利用合成方法制备功能化的有机分子，定量测量自然界中浓度极低的小分子. My research interest includes: 1) design novel sensing switches with high affinity and sensitivity to target molecules based on molecular recognition; 2) develop novel fluorescent molecules and understand their fluorescence features; 3) use designed sensing approaches to investigate the roles of important molecules in the biological systems; 4) use nanoparticles to improve the stability and permeability of fluorescence sensors for their biological applications.


Publications

 *为通讯作者 

32. Jeong, C-H.ǂ; Ahmad, A.ǂ; Schmitz, H.ǂ; Cao, H.*, Synthesis and investigation of derivatives of 1,通过芳香亲核取代反应获得长发射波长的8-萘酰亚胺. J. Fluoresc., 2022, 32, 427-433
31. Everitt, K. R.ǂ; Schmitz, H. C.ǂ; Macke, A.ǂ; Shan, J.ǂ; Jang, E.ǂ; Luedtke, B. E.; Carlson, K. A.;  Cao, H.*, 基于亲核加成反应的亚硫酸氢盐定量检测策略研究3-), J. Fluoresc., 2020, 30, 977-983.
30. Houtwed, H.ǂ; Xie, M.ǂ; Ahmad, A.ǂ; Masters, C. D.ǂ; Davison, M.ǂ; Ding, T.ǂ; Kounovsky-Shafer, K.; Cao, H.*，微流控通道中氰-3 (NCy3)硝基衍生物亚硫酸根的分析， J. Fluoresc., 2019, 29, 523-529. 
29.Jang, E.ǂ; Ding, T.ǂ; Xie, M.ǂ; Cao, H.*, Investigation of photophysical properties of 1,通过Suzuki偶联反应扩展共轭萘部分的8-萘酰亚胺, J. Photochem. Photobiol., A  2018, 364, 145-150                     
28.  Kim, G.ǂ; Jang, E.ǂ; Page, A.M.ǂ; Ding, T.ǂ; Carlson, K.A.; Cao, H.*, 叠氮化物快速还原选择性测定氢的生物利用度的传感方法研究2S, RSC Advances, 2016, 6, 95920-95924.                      
27. Bamesberger, A.ǂ; Kim, G.ǂ; Woo, Jǂ.; Cao, H.*, Reduction of nitro group on derivative of 1,8-萘酰亚胺用于硫化氢的定量检测, J. Fluoresc., 2015, 25, 25-29.
26. Woo, J.ǂ; Kim, G.ǂ; Qintero, K.ǂ;Hanrahan, M.P.ǂ; Palencia. H.; Cao, H.*, 脱硅作用对氟离子识别机制的研究,8-naphthalimide derivative, Org. Biomol. Chem., 2014, 12, 8275-8279.
25. Song, Q. ǂ; Bamesberger, A. ǂ; Yang, L. ǂ; Houtwed, H. ǂ; Cao, H.*准分子-单体开关:一种基于反应的氟化物选择性检测方法; Analyst, 2014, 139, 3588-3592.  
24. Bamesbergera, A.ǂ; Schwartza, C.; Song, Q. ǂ; Han, W.; Wang, Z.; Cao, H.*合理设计一种快速荧光法检测MeCN/H中无机氟2O:一种基于芳基1,8-萘酰亚胺的新型荧光开关， New. J. Chem., 2014, 38, 884-888.
23.Yang, L. ǂ; Song, Q. ǂ; Damit-Og, K. ǂ; Cao, H.*高铜亲和力荧光传感器的合成与光谱研究2+, Sensor Actuat B-Chem., 2013, 176, 181-185.
22. Wang, J. ǂ; Yang, L. ǂ; Hou, C. ǂ; Cao, H.*, A new N-咪唑-1,8-萘酰亚胺氟检测荧光传感器; Org. Biomol. Chem., 2012, 10, 6271-6274.
21. Hou, C. ǂ; Urbanec, A.M. ǂ; and Cao, H.*基于aza-15-冠-5醚功能化1,8-萘酰亚胺的Hg2+快速传感器 Tetrahedron Lett., 2011, 4903-4905.
20. Hou, C. ǂ; Xiong, Y.; Fu, N.; Jacquot, C.C. ǂ; Squier, T.C.; and Cao, H.*开启比例荧光传感器用于Pb(II)检测 Tetrahedron Lett., 2011, 2692-2696.
19. Yang, Y. ǂ; Gou, X.; Blecha, J. ǂ; Cao, H.*一种高选择性芘基汞荧光传感器2+ detection Tetrahedron Lett., 2010, 3422-3425.
18. Gou, X.; Cao, H.*中国高校本科化学教育 J. Chem. Educ.2010, 87 (6) 575-577.

Publication Prior to bet36365体育

17. Cao, H.; Xiong, Y.; Wang, T.; Squier, T.C.; Mayer, M. U.基于cy3的红色双砷荧光探针靶向互补结合肽 J. Am. Chem. Soc., 2007, 129, 8672-8673, Highlighted in Nature, 2007, 448, July 5th, 4
16. Chen, B.; Cao, H.; Yan, P; Mayer, M.U.; Squier, T.C.二砷多用途亲和探针正交肽结合基序的鉴定 Bioconjugate Chem., 2007, 1269-1265.
15. Cao, H.; Chen, B.; Squier, T.C.; Mayer, M.U.CrAsH:一种低非特异性荧光的双砷多用途亲和探针 Chem. Commun. 2006, 2601-2603.
14. Cao, H.; Chang, V.; Hernandez, R.; Heagy, M.D., Matrix library screening of substituted N-芳基1,8-萘酰亚胺揭示了新的双荧光染料和异常明亮的吡啶衍生物 J.Org .Chem., 2005, 70, 4929-4934.
13. Cao, H.; McGill, T.; Heagy, M.D.基于糖的单硼酸传感器的取代效应 N -phenyl-1,8-naphthalenedicarboximides J. Org. Chem., 2004, 2959-2966.
12. Cao, H.; Heagy, M.D., 碳水化合物荧光化学传感器:十年来糖的明亮间谍回顾 J. Fluorescence, 2004, 569-584.
11. Geddes, CD.; Cao, H.; Gryczynski, I.; Gryczynski, Z.; Fang, J.; Lakowicz, J.R., 平面上银固体的金属增强荧光(MEF):吲哚菁绿在体内成像中的潜在应用 J. Phys. Chem. A , 2003, 3443-3449.
10. Geddes, C.D.; Cao, H.; Lakowicz, J.R.在金胶体附近增强ICG的光稳定性 Spectrochimica Acta A, 2003, 2611-2617.
9. Sun, H.; Cao, H.; Luo, G.棕榈酰改性SOD的制备及性能 Chinese J. Bioprocess. Eng., 2003, 47-51.
8. Cao, H.; Diaz, D.I.; DiCesare, N.; Lakowicz, J.R., Heagy, M.D.显示对葡萄糖异常荧光敏感性的单硼酸传感器 Org. Lett., 2002, 1503-1505.
7. Liang, F.; Wu, Y.; Cao, H.; Guo, H.; Liu, L.; Sun, H.; Chen, W.; Liu, S., Chemical modification of human plasminogen Chem. J. Chinese Univ. 2001, 22(4) 577-580.
6. Xu, J.; Ma, J.; Xu, H.; Ma, Z.; Kong, X.; Cao, H.; Guo, H.; Liu, L.普鲁兰的分离纯化及其对绿茶中多酚茶的保护作用 吉林大学学报(自然科学版) 2001, 88-90.
5. Cao, H.; Sun, H.; Liang, F.; Guo, H.; Liu, L., Purification and identification of pulullan Chem. J. Chinese Univ. 1999, 20(12) 78-84.
4. Yang, F.; Guo, H.; Xu, H.; Cao, H.; Liu, L., 乌苏里蝮蛇毒液凝血酶样酶产物的生化分析 吉林大学学报(自然科学版), 1999, (2) 79-82.
3. Yang, F.; Xu, H.; Guo, H;, Cao, H.; Liu, L., 乌苏里蝮蛇毒液中凝血酶样酶的纯化及质量控制 Chin. J. Biologicals, 1999, (12) 100-102.
2. Qiu, A.; Sun, H.; Zhong, H.; Liu, S.; Zhao, C.; Wu, Y.; Cao, H.; Liu, L., Purification and properties of human plasminogen 吉林大学学报(自然科学版) 1998, (3) 79-81.
1. Zhao, H.; Li, C.; Xue, Y.; Zhang, L.; Cao, H.; Guo, H.; Liu, L.蒲鲁兰高产菌株的突变与筛选 吉林大学学报(自然科学版) 1998, (3) 75-78.
 

Research Opportunities

我们的小组为bet36365体育学生提供研究机会，无论专业如何. 目前，有几个项目可以帮助学生开展研究. Please feel free to contact Dr. 如果你对研究感兴趣，特别是有机/生物有机化学.